Spotlight on Mazdutide: The Dual GLP-1/Glucagon Agonist Advancing Metabolic Research in 2025

Mazdutide (IBI362 / LY-3305677) – a long-acting dual receptor agonist that’s making waves in metabolic pathway studies with its unique oxyntomodulin-inspired design. Mazdutide stands out as a synthetic analogue of oxyntomodulin, engineered for balanced activation of both GLP-1 and glucagon receptors. This dual agonism opens intriguing possibilities for laboratory exploration of glucose regulation combined with energy expenditure mechanisms. Key Structural & Mechanistic Highlights (From Published Literature) Dual Agonism: Targets GLP-1R (incretin effects, insulin secretion) and GCGR (hepatic glucose modulation, lipolysis promotion). Molecular Design: Acylated peptide with extended half-life, supporting weekly protocols in experimental settings. Recent Clinical Insights (2025 Updates): Phase 1b data in adolescents showed notable BMI/weight reductions and metabolic improvements; Phase 3 trials (e.g., DREAMS-1/2 published in Nature, GLORY-1 in NEJM) demonstrated efficacy in glycemic control and weight management models, with ongoing studies in related conditions. link.springer.comnature.comsciencedirect.comtandfonline.com Illustrative examples of dual agonist peptide structures and receptor pathways (peer-reviewed sources) These peer-reviewed findings emphasize Mazdutide’s role in advanced in vitro and preclinical metabolic research – strictly without human implications. Why Researchers Are Choosing Mazdutide Now ≥99% purity with comprehensive third-party HPLC/MS COAs per batch 100mg format ideal for extended assays and comparative studies vs single agonists Excellent solubility for precise reconstitution in lab protocols All GoodGainsLabs Mazdutide is provided exclusively for laboratory research – not for human or veterinary use. erospeptides.compeptidepowerhouse.comumbrellalabs.isumbrellalabs.is Example lab-grade lyophilized peptide vials (illustrative – actual product sealed with COA) Next up in the series: another standout from our featured metabolic collection. Research inquiries on batch reports or storage? Comment below. Research Use Only • Not for Human Consumption • 21+ Only – The GoodGainsLabs Team